Looking for the best tirzepatide pharmacy right now? Pricing shifted dramatically in late 2025 when Eli Lilly dropped LillyDirect vial prices and compounding enforcement tightened. Here's what's actually available in January 2026.
Bottom line: Brand-name Zepbound via LillyDirect now starts at $299/month for the 2.5mg dose—cheaper than many compounded options. But compounded tirzepatide (where still legally available) ranges from $224-$349/month depending on provider.
Brand Tirzepatide: LillyDirect Pricing (January 2026)
LillyDirect reduced Zepbound vial prices on December 1, 2025. These are authentic, FDA-approved tirzepatide shipped directly from Eli Lilly:
| Dose | Monthly Price | Notes |
|---|---|---|
| 2.5mg vial | $299 | Starter dose |
| 5mg vial | $399 | First maintenance dose |
| 7.5-15mg vials | $449 | With 45-day refill* |
| With insurance + savings card | $25 | Commercial insurance only |
*Higher doses cost $599-$1,049 without the Self Pay Journey Program's 45-day refill requirement. Vials also available for pickup at Walmart pharmacies nationwide.
Compounded Tirzepatide Providers (January 2026)
Compounded tirzepatide remains available through providers who prescribe formulations with clinical differences (added B6, B12, or modified dosing). Here are current options:
| Provider | True Monthly Cost | Format | Notes |
|---|---|---|---|
| SkinnyRx | $179-$300 | Injectable | No sign-up fee |
| Elevate Health | From $199 | Injectable | Telehealth included |
| TMates GLP-1 | From $249 | Injectable | Personalized dosing |
Which Should You Choose?
The calculation has changed. With LillyDirect's new pricing:
Choose brand Zepbound if: You want FDA-approved medication with guaranteed potency, you're on a maintenance dose under 5mg, or you have commercial insurance (potential $25/month).
Choose compounded if: You need custom dosing, you're on high doses (10-15mg) and want flat pricing, or you prefer oral tablets over injections.
Coming Soon: Medicare Coverage
If you're on Medicare, mark your calendar. The Trump administration's deal with Lilly and Novo Nordisk means:
- • July 2026: Medicare bridge program launches (~$50/month copay)
- • January 2027: Full Part D pilot begins
- • Eligibility: BMI >27 with prediabetes/CVD, or BMI >30 with hypertension/kidney disease/heart failure
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